Continuous-Flow Microreactor Chemistry under High-Temperature/Pressure Conditions

Authors

  • Tahseen Razzaq,

    1. Christian Doppler Laboratory for Microwave Chemistry (CDLMC) and Institute of Chemistry, Karl-Franzens-University Graz, Heinrichstrasse 28, 8010 Graz, Austria, Fax: +43-316-380-9840
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  • Toma N. Glasnov,

    1. Christian Doppler Laboratory for Microwave Chemistry (CDLMC) and Institute of Chemistry, Karl-Franzens-University Graz, Heinrichstrasse 28, 8010 Graz, Austria, Fax: +43-316-380-9840
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  • C. Oliver Kappe

    1. Christian Doppler Laboratory for Microwave Chemistry (CDLMC) and Institute of Chemistry, Karl-Franzens-University Graz, Heinrichstrasse 28, 8010 Graz, Austria, Fax: +43-316-380-9840
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Abstract

High-temperature organic synthesis can be performed under continuous-flow conditions in a stainless steel microtubular flow reactor capable of achieving temperatures of 350 °C and 200 bar. Under these extreme experimental environments transformations normally performed in a high-boiling solvent at reflux temperature – or under sealed-vessel microwave conditions – can be readily converted to a flow regime by using lower boiling solvents in or near their supercritical state.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

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