Green Synthesis of Vicinal Dithioethers and Alkenyl Thioethers from the Reaction of Alkynes and Thiols in Water



The reaction of a wide range of alkynes with thiols to give vicinal dithioethers in water, under mild conditions, is reported. In addition, non-terminal propargyl alcohols react with aryl thiols in water to produce a highly regio- andstereoselective monohydrothiolation product, (E)-alkenyl thioether. Reaction mechanism and computational studies on the selectivity of the product are presented.