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Abstract

The cover picture shows the binding of an influenza virus to the surface of a host cell. The hemaglutinin (blue spikes) binds to the sialic acid (green hexagons) residues present on the non-reducing end of the surface glycoprotein to gain entry into the cell. Once the cell is infected, the viral neuraminidases (pink pinwheels) cleave the sialic acids to escape. The 1,2,3-triazole-linked sialic acid derivatives (green spheres) were designed to act as non-hydrolyzable inhibitors to block the virus. Details are discussed in the article by R. J. Linhardt et al. on p. 2611 ff.