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Synthesis and Biological Evaluation of Non-Hydrolyzable 1,2,3-Triazole-Linked Sialic Acid Derivatives as Neuraminidase Inhibitors (Eur. J. Org. Chem. 16/2009)
Article first published online: 11 MAY 2009
DOI: 10.1002/ejoc.200990041
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Weïwer, M., Chen, C.-C., Kemp, M. M. and Linhardt, R. J. (2009), Synthesis and Biological Evaluation of Non-Hydrolyzable 1,2,3-Triazole-Linked Sialic Acid Derivatives as Neuraminidase Inhibitors (Eur. J. Org. Chem. 16/2009). Eur. J. Org. Chem., 2009: 2587. doi: 10.1002/ejoc.200990041
Publication History
- Issue published online: 11 MAY 2009
- Article first published online: 11 MAY 2009
- Abstract
- Cited By
Abstract
The cover picture shows the binding of an influenza virus to the surface of a host cell. The hemaglutinin (blue spikes) binds to the sialic acid (green hexagons) residues present on the non-reducing end of the surface glycoprotein to gain entry into the cell. Once the cell is infected, the viral neuraminidases (pink pinwheels) cleave the sialic acids to escape. The 1,2,3-triazole-linked sialic acid derivatives (green spheres) were designed to act as non-hydrolyzable inhibitors to block the virus. Details are discussed in the article by R. J. Linhardt et al. on p. 2611 ff.