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Transition-Metal-Mediated or -Catalyzed Syntheses of Steroids and Steroid-Like Compounds

Authors

  • Martin Kotora,

    1. Dept. of Organic and Nuclear Chemistry, Faculty of Science, Charles University in Prague, Hlavova 8, 12843 Praha 2, Czech Republic, Fax: +420-221-951-326
    2. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., Flemingovo nám. 2, 166 10 Praha 6, Czech Republic
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  • Filip Hessler,

    1. Dept. of Organic and Nuclear Chemistry, Faculty of Science, Charles University in Prague, Hlavova 8, 12843 Praha 2, Czech Republic, Fax: +420-221-951-326
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  • Barbara Eignerová

    1. Dept. of Organic and Nuclear Chemistry, Faculty of Science, Charles University in Prague, Hlavova 8, 12843 Praha 2, Czech Republic, Fax: +420-221-951-326
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Abstract

This short review aims to summarize recent advances in the use of transition-metal-catalyzed and -mediated methodology for the synthesis of steroid and steroid-like skeletons reported in the last decade. The methodologies used include transition-metal-catalyzed or -mediated [2+2+2] and other cycloadditions, the Pauson–Khand reaction, cross-coupling and Heck reactions, processes based on the activation of single and multiple bonds, metathesis reactions, hydrovinylation, and other reactions. Several examples of total synthesesof steroid compounds [e.g., (+)- and (–)-estrone, desogestrel] by these procedures are presented.

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