The New Age of Electrophilic Perfluoro­alk­ylation Reactions

Authors

  • Yohan Macé,

    1. Institut Lavoisier de Versailles, UMR CNRS 8180, Université de Versailles, St Quentin en Yvelines, 45 avenue des Etats-Unis, 78035 Versailles Cedex, France, Fax: +33-1-39254452
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  • Emmanuel Magnier

    1. Institut Lavoisier de Versailles, UMR CNRS 8180, Université de Versailles, St Quentin en Yvelines, 45 avenue des Etats-Unis, 78035 Versailles Cedex, France, Fax: +33-1-39254452
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  • Dedicated to the memory of Professor Lev Yagupolskii

  • A pioneer in electrophilic perfluoroalkylation chemistry

Abstract

The introduction of a perfluoroalkyl group, with emphasis on the trifluoromethyl moiety, is a challenging topic. Of the synthetic methods available in the repertoire of chemists, electrophilic introduction was until recently the least developed. In five years, however, a renaissance of this chemistry has happened. This renewal has been made possible thanks to reports both of numerous new reagents (stable, easy tohandle and to prepare) and of easier preparation of older reagents. Their availability rapidly inspired highly original works involving their use, in particular with the help of catalysis. This virtuous spiral, as well as all these exciting new developments, is described in this microreview.

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