An Improved Copper-Mediated Oxidative Trifluoromethylation of Terminal Alkynes

Authors

  • Ke Zhang,

    1. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University 2999 North Renmin Road, Shanghai 201620, China
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  • Xiao-Long Qiu,

    1. Wisdom Pharmaceutical Co., Ltd., 601 East Xiu-shan Road, Haimen, Jiangsu Province 226100, China
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  • Yangen Huang,

    1. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University 2999 North Renmin Road, Shanghai 201620, China
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  • Feng-Ling Qing

    1. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University 2999 North Renmin Road, Shanghai 201620, China
    2. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science 345 Lingling Road, Shanghai 200032, China
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Abstract

An improved method for the efficient copper-mediated trifluoromethylation of terminal alkynes has been developed. This protocol highlights the convenient access to a variety of aryl-substituted trifluoromethylated alkynes by oxidative trifluoromethylation with two equivalents of TMSCF3 at room temperature.

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