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A BODIPY-Based Highly Selective Fluorescent Chemosensor for Hg2+ Ions and Its Application in Living Cell Imaging

  1. Mani Vedamalai,
  2. Shu-Pao Wu

Article first published online: 4 JAN 2012

DOI: 10.1002/ejoc.201101623

Issue

European Journal of Organic Chemistry

European Journal of Organic Chemistry

Volume 2012, Issue 6, pages 1158–1163, February 2012

Additional Information

How to Cite

Vedamalai, M. and Wu, S.-P. (2012), A BODIPY-Based Highly Selective Fluorescent Chemosensor for Hg2+ Ions and Its Application in Living Cell Imaging. Eur. J. Org. Chem., 2012: 1158–1163. doi: 10.1002/ejoc.201101623

Author Information

  1. Department of Applied Chemistry, National Chiao Tung University, Hsinchu, Taiwan, Republic of China, Fax: +886-3-5723764

Publication History

  1. Issue published online: 13 FEB 2012
  2. Article first published online: 4 JAN 2012
  3. Manuscript Received: 10 NOV 2011

Funded by

  • National Science Council (ROC)
  • National Chiao Tung University

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Keywords:

  • Sensors;
  • Mercury;
  • Fluores­cence;
  • Imaging agents

Abstract

A new boron–dipyrromethene (BODIPY) derivative (FS1) containing two triazole units exhibits an enhanced fluorescence in the presence of Hg2+ ions and a high selectivity for Hg2+ ions over competing metal ions in methanol: Ag+, Ca2+, Cd2+, Co2+, Cu2+, Fe2+, Fe3+, K+, Mg2+, Mn2+, Ni2+, Pb2+, and Zn2+ produced only minor changes in the fluorescence of FS1. The apparent dissociation constant (Kd) of FS1–Hg2+ was found to be 62 μM. Moreover, fluorescence microscopy experiments showed that FS1 can be used as a fluorescent probe for detecting Hg2+ ions in living cells.

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