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1H-Isoindole-Based Potential Peptidomimetics

  1. Angelina V. Biitseva1,
  2. Igor V. Rudenko1,
  3. Olga V. Hordiyenko1,
  4. Brigitte Jamart-Grégoire2,
  5. Axelle Arrault2

Article first published online: 29 JUN 2012

DOI: 10.1002/ejoc.201200238

Issue

European Journal of Organic Chemistry

European Journal of Organic Chemistry

Volume 2012, Issue 23, pages 4387–4394, August 2012

Additional Information

How to Cite

Biitseva, A. V., Rudenko, I. V., Hordiyenko, O. V., Jamart-Grégoire, B. and Arrault, A. (2012), 1H-Isoindole-Based Potential Peptidomimetics. Eur. J. Org. Chem., 2012: 4387–4394. doi: 10.1002/ejoc.201200238

Author Information

  1. 1

    Department of Chemistry, National Taras Shevchenko University of Kyiv, 64, Volodymyrs'ka st., Kyiv, 01601, Ukraine

  2. 2

    Laboratoire de Chimie Physique Macromoléculaire, UMR 7568 (CNRS-INPL), 1 rue Grandville, BP 20451, 54001 Nancy Cedex, France

Publication History

  1. Issue published online: 1 AUG 2012
  2. Article first published online: 29 JUN 2012
  3. Manuscript Received: 28 FEB 2012

Funded by

  • Ministry of Education and Science of Ukraine (French-Ukrainian program DNIPRO)
  • Ministry for Foreign Affairs of France (EGIDE)
  • la Région Lorraine
  • INPL of Nancy

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Keywords:

  • Amino acids;
  • Peptidomimetics;
  • Protein folding;
  • Protein design;
  • Hydraz­ones

Abstract

A variety of 1H-isoindole-based peptides was designed as potential mimics, and their efficient synthesis starting from 1-imino-1H-isoindol-3-amine by subsequent interaction with N-Boc-amino acid hydrazides and amino acid ester isocyanates generated in situ, followed by chain elongation using conventional peptide chemistry, was elaborated.

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