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Microwave-Assisted Formation of Peptide–Vitamin Conjugates

  1. Claudia El-Nachef1,
  2. Kiran Bajaj1,
  3. Jacqueline Koblick1,
  4. Alan R. Katritzky1,2

Article first published online: 21 JUN 2012

DOI: 10.1002/ejoc.201200323

Issue

European Journal of Organic Chemistry

European Journal of Organic Chemistry

Volume 2012, Issue 23, pages 4412–4419, August 2012

Additional Information

How to Cite

El-Nachef, C., Bajaj, K., Koblick, J. and Katritzky, A. R. (2012), Microwave-Assisted Formation of Peptide–Vitamin Conjugates. Eur. J. Org. Chem., 2012: 4412–4419. doi: 10.1002/ejoc.201200323

Author Information

  1. 1

    Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA

  2. 2

    Department of Chemistry, King Abdulaziz University, Jeddah 21589, Saudi Arabia

Publication History

  1. Issue published online: 1 AUG 2012
  2. Article first published online: 21 JUN 2012
  3. Manuscript Received: 15 MAR 2012

Funded by

  • University of Florida
  • The Kenan Foundation
  • King Abdulaziz University, Jeddah, Saudi Arabia

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Keywords:

  • Microwave chemistry;
  • Peptides;
  • Amino acids;
  • Vitamins

Abstract

Amino acid and peptide conjugates with vitamin B3, H, E and D3 were synthesized by using microwave irradiation in good to satisfactory yields. In addition, a novel benzotriazole-activated biotin intermediate has been introduced, which could serve as an alternative biotinylation agent.

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