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Full Paper
2,6-Dimethoxyphenyl-Substituted N-Heterocyclic Carbenes (NHCs): A Family of Highly Electron-Rich Organocatalysts
Article first published online: 19 JUN 2012
DOI: 10.1002/ejoc.201200408
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Schedler, M., Fröhlich, R., Daniliuc, C.-G. and Glorius, F. (2012), 2,6-Dimethoxyphenyl-Substituted N-Heterocyclic Carbenes (NHCs): A Family of Highly Electron-Rich Organocatalysts. Eur. J. Org. Chem., 2012: 4164–4171. doi: 10.1002/ejoc.201200408
Publication History
- Issue published online: 23 JUL 2012
- Article first published online: 19 JUN 2012
- Manuscript Received: 29 MAR 2012
Funded by
- Fonds der Chemischen Industrie
- Deutsche Forschungsgemeinschaft (DFG). Grant Number: SPP 1179
- Alfried Krupp von Bohlen und Halbach Foundation
Keywords:
- Carbenes;
- Organocatalysis;
- Umpolung;
- Hydroacylation
Abstract
Based on our recent finding that 2,6-dimethoxyphenyl-substituted NHCs show superior reactivity in the hydroacylation reactions of electron-neutral olefins compared with known NHCs, we now report the syntheses and crystal structures of four highly electron-rich 2,6-dimethoxyphenyl-substituted NHCs and show the increase in efficiency caused by the electron-rich aryl substituent in hydroacylation reactions.