2,6-Dimethoxyphenyl-Substituted N-Heterocyclic Carbenes (NHCs): A Family of Highly Electron-Rich Organocatalysts

Authors

  • Michael Schedler,

    1. Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstrasse 40, 48149 Münster, Germany, Fax: +49-251-8333202
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  • Roland Fröhlich,

    1. Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstrasse 40, 48149 Münster, Germany, Fax: +49-251-8333202
    2. Laboratory of Single-Crystal X-ray Structure Determination, Westfälische Wilhelms-Universität Münster, Organisch- Chemisches Institut, Corrensstrasse 40, 48149 Münster, Germany, Fax: +49-251-83-33293
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  • Constantin-G. Daniliuc,

    1. Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstrasse 40, 48149 Münster, Germany, Fax: +49-251-8333202
    2. Laboratory of Single-Crystal X-ray Structure Determination, Westfälische Wilhelms-Universität Münster, Organisch- Chemisches Institut, Corrensstrasse 40, 48149 Münster, Germany, Fax: +49-251-83-33293
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  • Frank Glorius

    1. Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstrasse 40, 48149 Münster, Germany, Fax: +49-251-8333202
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Abstract

Based on our recent finding that 2,6-dimethoxyphenyl-substituted NHCs show superior reactivity in the hydroacylation reactions of electron-neutral olefins compared with known NHCs, we now report the syntheses and crystal structures of four highly electron-rich 2,6-dimethoxyphenyl-substituted NHCs and show the increase in efficiency caused by the electron-rich aryl substituent in hydroacylation reactions.

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