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Keywords:

  • Amination;
  • Cross-coupling;
  • Palladium;
  • Ligand design

Abstract

We report on the application of the [Pd(cinnamyl)Cl]2/Mor-DalPhos catalyst system in the Buchwald–Hartwig amination of (hetero)aryl chlorides with primary or secondary amines conducted either under aqueous conditions without the use of co-solvents and/or surfactants or under solvent-free conditions (52 examples). We have established that reactions of this type can be conducted without the rigorous exclusion of air, and in the case of the solvent-free reactions, we have demonstrated that appropriately selected liquid and solid reagents can be employed successfully.