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Three-Component, One-Pot Sequential Synthesis of Tetracyclic Pyrido[2′,1′:2,3]imidazo[5,1-a]isoquinolinium Compounds as Potent Anticancer Agents

  1. Huayong Zhou1,
  2. Wei Wang1,
  3. Oleg Khorev2,
  4. Yongliang Zhang1,
  5. Zehong Miao1,
  6. Tao Meng1,
  7. Jingkang Shen1

Article first published online: 17 AUG 2012

DOI: 10.1002/ejoc.201200542

Issue

European Journal of Organic Chemistry

European Journal of Organic Chemistry

Volume 2012, Issue 28, pages 5585–5594, October 2012

Additional Information

How to Cite

Zhou, H., Wang, W., Khorev, O., Zhang, Y., Miao, Z., Meng, T. and Shen, J. (2012), Three-Component, One-Pot Sequential Synthesis of Tetracyclic Pyrido[2′,1′:2,3]imidazo[5,1-a]isoquinolinium Compounds as Potent Anticancer Agents. Eur. J. Org. Chem., 2012: 5585–5594. doi: 10.1002/ejoc.201200542

Author Information

  1. 1

    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, P. R. China, Fax: +86-21-50807088, http://www.simm.ac.cn/

  2. 2

    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland

Publication History

  1. Issue published online: 18 SEP 2012
  2. Article first published online: 17 AUG 2012
  3. Manuscript Received: 25 APR 2012

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Keywords:

  • Heterocycles;
  • Alkynes;
  • Silver;
  • Multicomponent reactions;
  • Antiproliferation

Abstract

A new practical method for the synthesis of tetracyclic pyrido[2′,1′:2,3]imidazo[5,1-a]isoquinolinium compounds by a Yb(OTf)3/AgOTf-catalyzed (Tf = triflate) three-component domino reaction was developed. Significantly, the strategy presents a straightforward and efficient approach to constructing a series of compounds with potent cytotoxic activities.

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