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Short Communication
Cross-Coupling of N-Allylic Sulfonimides with Organozinc Reagents at Room Temperature
Article first published online: 21 JUN 2012
DOI: 10.1002/ejoc.201200594
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Tang, X.-L., Wu, Z., Li, M.-B., Gu, Y. and Tian, S.-K. (2012), Cross-Coupling of N-Allylic Sulfonimides with Organozinc Reagents at Room Temperature. Eur. J. Org. Chem., 2012: 4107–4109. doi: 10.1002/ejoc.201200594
Publication History
- Issue published online: 23 JUL 2012
- Article first published online: 21 JUN 2012
- Manuscript Received: 7 MAY 2012
Funded by
- National Natural Science Foundation of China. Grant Numbers: 21172206, 21072180, 20972147, J1030412
- National Basic Research Program of China. Grant Number: 973 Program 2010CB833300
- Program for Changjiang Scholars and Innovative Research Team in University. Grant Number: IRT1189
Keywords:
- Sulfur;
- Alkenes;
- Cross-coupling;
- Zinc;
- Palladium
Abstract
An efficient cross-coupling reaction of N-allylic sulfonimides with organozinc reagents has been developed. In the presence of 1 mol-% of Pd2(dba)3, a range of N-allylic sulfonimides smoothly couple with various organozinc reagents at room temperature to give the corresponding (E)-alkene products in moderate to excellent yields and with good to exclusive α-selectivity. It is noteworthy that allyl ether, benzyl ether, and ester are tolerated under the reaction conditions.