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Microreview
Domino Reactions Initiated by Enantioselective Cu-Catalyzed Conjugate Addition
Article first published online: 24 SEP 2012
DOI: 10.1002/ejoc.201200875
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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How to Cite
Galeštoková, Z. and Šebesta, R. (2012), Domino Reactions Initiated by Enantioselective Cu-Catalyzed Conjugate Addition. Eur. J. Org. Chem., 2012: 6688–6695. doi: 10.1002/ejoc.201200875
Publication History
- Issue published online: 20 NOV 2012
- Article first published online: 24 SEP 2012
- Manuscript Received: 3 JUL 2012
- Abstract
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Keywords:
- Asymmetric catalysis;
- Domino reactions;
- 1,4-Addition;
- Copper;
- Enolates
Abstract
Enantioselective copper-catalyzed 1,4-additions of organometallic reagents are useful components of domino reactions. Enolates resulting from such additions readily react with a range of electrophilic reagents, such as aldehydes and acetals, alkyl and allyl halides and halide surrogates, epoxides, imines, nitroalkenes, and α,β-unsaturated carbonyl compounds. The aim of this review is to give an overview of domino transformations based on Cu-catalyzed conjugate addition. Special emphasis is placed on the most recent work and also on that utilized in the synthesis of complex target molecules.