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Keywords:

  • Asymmetric catalysis;
  • Domino reactions;
  • 1,4-Addition;
  • Copper;
  • Enolates

Abstract

Enantioselective copper-catalyzed 1,4-additions of organometallic reagents are useful components of domino reactions. Enolates resulting from such additions readily react with a range of electrophilic reagents, such as aldehydes and acetals, alkyl and allyl halides and halide surrogates, epoxides, imines, nitroalkenes, and α,β-unsaturated carbonyl compounds. The aim of this review is to give an overview of domino transformations based on Cu-catalyzed conjugate addition. Special emphasis is placed on the most recent work and also on that utilized in the synthesis of complex target molecules.