Get access

Domino Reactions Initiated by Enantioselective Cu-Catalyzed Conjugate Addition



Enantioselective copper-catalyzed 1,4-additions of organometallic reagents are useful components of domino reactions. Enolates resulting from such additions readily react with a range of electrophilic reagents, such as aldehydes and acetals, alkyl and allyl halides and halide surrogates, epoxides, imines, nitroalkenes, and α,β-unsaturated carbonyl compounds. The aim of this review is to give an overview of domino transformations based on Cu-catalyzed conjugate addition. Special emphasis is placed on the most recent work and also on that utilized in the synthesis of complex target molecules.

Get access to the full text of this article