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Full Paper
Discovery of a Robust and Efficient Homogeneous Silver(I) Catalyst for the Cycloaddition of Azides onto Terminal Alkynes
Article first published online: 17 AUG 2012
DOI: 10.1002/ejoc.201200930
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
McNulty, J. and Keskar, K. (2012), Discovery of a Robust and Efficient Homogeneous Silver(I) Catalyst for the Cycloaddition of Azides onto Terminal Alkynes. Eur. J. Org. Chem., 2012: 5462–5470. doi: 10.1002/ejoc.201200930
Publication History
- Issue published online: 18 SEP 2012
- Article first published online: 17 AUG 2012
- Manuscript Received: 13 JUL 2012
Keywords:
- Cycloaddition;
- Azides;
- Alkynes;
- Click chemistry;
- Silver
Abstract
A highly efficient, chemically stable, and well-defined homogeneous silver(I) catalyst is reported for the cycloaddition of azides onto terminal alkynes (Ag-AAC reaction). The Ag-AAC reaction occurs at room temperature or with heating to deliver exclusively the corresponding 1,4-triazole. A pronounced ligand effect was discovered through systematic modification to the ligand structure resulting in the discovery of a chemically stable active catalyst for this reaction.