Short Communication

Acetamide as Cocatalyst for the Nitrogen-Directed Coupling of Arenes with Aryl Chlorides through Ruthenium-Catalyzed C–H Activation

  1. Jie Zhang,
  2. Qin Yang,
  3. Zhu Zhu,
  4. Mao Lin Yuan,
  5. Hai Yan Fu,
  6. Xue Li Zheng,
  7. Hua Chen,
  8. Rui Xiang Li

Article first published online: 30 OCT 2012

DOI: 10.1002/ejoc.201201127

Issue

European Journal of Organic Chemistry

European Journal of Organic Chemistry

Volume 2012, Issue 34, pages 6702–6706, December 2012

Additional Information

How to Cite

Zhang, J., Yang, Q., Zhu, Z., Yuan, M. L., Fu, H. Y., Zheng, X. L., Chen, H. and Li, R. X. (2012), Acetamide as Cocatalyst for the Nitrogen-Directed Coupling of Arenes with Aryl Chlorides through Ruthenium-Catalyzed C–H Activation. Eur. J. Org. Chem., 2012: 6702–6706. doi: 10.1002/ejoc.201201127

Author Information

  1. Key Laboratory of Green Chemistry and Technology, Ministry of Education, Sichuan University, Chengdu, Sichuan 610064, People's Republic of China, Fax: +86-28-8541-2904, http://chem.scu.edu.cn/

Publication History

  1. Issue published online: 20 NOV 2012
  2. Article first published online: 30 OCT 2012
  3. Manuscript Received: 18 AUG 2012

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Keywords:

  • Ruthenium;
  • C–H activation;
  • Arenes;
  • Cross-coupling;
  • Biaryls

Abstract

A simple and highly efficient method for the cross-coupling of aromatics by C–H activation is described. Acetamide was found to be an effective cocatalyst for this generally applicable ruthenium(II)-catalyzed direct arylation reaction. A wide range of deactivated aryl chlorides could be efficiently coupled under the mild temperature of 101 °C. The new process is highly atom-economical and sustainable.

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