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Keywords:

  • Ruthenium;
  • C–H activation;
  • Arenes;
  • Cross-coupling;
  • Biaryls

Abstract

A simple and highly efficient method for the cross-coupling of aromatics by C–H activation is described. Acetamide was found to be an effective cocatalyst for this generally applicable ruthenium(II)-catalyzed direct arylation reaction. A wide range of deactivated aryl chlorides could be efficiently coupled under the mild temperature of 101 °C. The new process is highly atom-economical and sustainable.