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Direct Access to Fully Substituted 3-Formyl-4-iodofurans through Iodocyclization of α-Alkynyl β-Alkoxy Enones

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Abstract

A facile access to 3-formyl-4-iodofurans is presented. This protocol consists of a Sonogashira cross-coupling of an α-iodo β-alkoxy enone with a terminal alkyne and the subsequent iodonium-promoted heteroannulation–dealkoxylation of the resulting α-alkynyl β-alkoxy enone by treatment with N-iodosuccinimide in aqueous medium.

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