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Keywords:

  • Synthetic methods;
  • Nitrogen heterocycles;
  • Fluorine;
  • Diastereoselec­tivity;
  • Annulation

Abstract

A highly regio- and stereoselective synthesis of pyrazolidine analogues by the use of N,N′-cyclic or C,N-cyclic azomethine imines with two different trifluoromethyl-containing olefins has been developed. The method affords highly functionalized trifluoromethyl-containing pyrazolidine analogues in excellent yields with high diastereoselectivities under mild conditions.