Gold-Catalyzed Mannich Addition Reactions of 1,3-Dicarbonyl Compounds with N-Protected Imines

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Abstract

The first (N-heterocyclic carbene)AuI-catalyzed Mannich addition reactions of N-protected imines with different 1,3-dicarbonyl compounds are described. IPrAuNTf2 was proven to be an efficient catalyst for the reactions of β-keto esters and 1,3-diketones with N-sulfonylimines to afford the desired β-amino carbonyl compounds in good yields under very mild conditions.

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