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Keywords:

  • Nitrogen heterocycles;
  • Cross-coupling;
  • C–C coupling;
  • Aldol reactions;
  • Palladium;
  • Microwave chemistry

Abstract

An efficient one-pot synthesis of naphthoxindoles by using 4-bromoindolin-2-ones and 2-formylphenylboronic acids has been developed. The coupling reaction proceeds in good to excellent yields under microwave irradiation through a Suzuki–Miyaura coupling and an aldol condensation cascade reaction. In addition, this protocol permits the facile construction of naphthoxindoles through an expanded scope of substrates.