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Keywords:

  • Small ring systems;
  • Allylic compounds;
  • Titanium;
  • Grignard reaction;
  • Synthetic methods

Abstract

The Kulinkovich cyclopropanation of esters with disubstituted homoallylic alcohols is described for the preparation of 1,2,3-trisubstituted cyclopropanols. Central to the successful implementation is the generation in situ of a temporary alkoxy tether between a homoallylic alcohol and an alkoxytitanium species to override unfavorable steric factors.