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Facile Assembly of 1-[(Trifluoromethyl)thio]isoquinolines through Reaction of 2-Alkynylbenzaldoxime with Silver (Trifluoromethyl)thiolate

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Abstract

1-[(Trifluoromethyl)thio]isoquinolines can be assembled through silver(I)-catalyzed reaction of 2-alkynylbenzaldoxime with silver (trifluoromethyl)thiolate in the presence of p-methoxybenzenesulfonyl chloride. The (trifluoromethyl)thio moiety (SCF3) could be easily introduced into the scaffold of isoquinoline under mild conditions.

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