Oxepinamides: Novel Liver X Receptor Agonists from Aspergillus puniceus (pages 802–807)
Xin-Hua Lu, Qing-Wen Shi, Zhi-Hui Zheng, Ai-Bing Ke, Hua Zhang, Chang-Hong Huo, Ying Ma, Xiao Ren, Ye-Ying Li, Jie Lin, Qin Jiang, Yu-Cheng Gu and Hiromasa Kiyota
Version of Record online: 13 DEC 2010 | DOI: 10.1002/ejoc.201000812
Oxepinamides D–G, which are four novel oxepin-containing pyrimidines, were isolated from cultures of Aspergillus puniceus F02Z-1744. All four compounds showed moderate transcriptional activation on LXRα (Liver X Receptor), whereas no effects were observed on FXRα, PPARα, PPARβ, PPARγ, RARα, RXRα, or ERα at concentrations of 30 μM.