Synthesis of Carbamates by Direct C–H Bond Activation of Formamides (pages 6760–6766)
Balaji D. Barve, Yang-Chang Wu, Mohamed El-Shazly, Da-Wei Chuang, Yu-Ming Chung, Yi-Hong Tsai, Shou-Fang Wu, Michal Korinek, Ying-Chi Du, Chi-Ting Hsieh, Jeh-Jeng Wang and Fang-Rong Chang
Article first published online: 22 OCT 2012 | DOI: 10.1002/ejoc.201201160
Synthesis of carbamates was accomplished through the reaction of β-keto esters or 2-carbonyl-substituted phenols with formamides using copper chloride and an oxidant. Sixteen aliphatic as well as fourteen aromatic carbamates were prepared in good to excellent yields. The methodology was applied to the synthesis of halogenated carbamates and a carbaryl insecticide derivative.