A Concise and Efficient Total Synthesis of Oleocanthal (pages 4332–4336)
Matteo Valli, Elena Giulia Peviani, Alessio Porta, Alessandro D'Alfonso, Giuseppe Zanoni and Giovanni Vidari
Version of Record online: 23 MAY 2013 | DOI: 10.1002/ejoc.201300324
Oleocanthal, a component of extra virgin olive oil, possesses anti-inflammatory activity and inhibits the formation of neurofibrillary tangles. In this paper, we have achieved the shortest synthesis of (±)-oleocanthal reported so far from easily available starting materials. Chiral chromatographic resolution of the mixture provided both enantiomers for biological studies.