The cover picture shows the structures of several 7-deazaguanosine (Q, galQ, preQ1, preQ0, gluQ, oQ) and the X-ray structure of tRNAAsp.The tRNA data was obtained from the pbd file of the strcuture published by Briand et al. (J. Mol. Biol. 2000, 299, 1051) containing the hypermodified nucleoside queuosine (Q) in the wobble position (position 34) and the image was created in PyMOL. Prokaryotes can synthesize Q de novo via epoxyqueuosine (oQ) as the direct biosynthesis precursor. The total synthesis of oQ discussed in the Short Communication by I. Thoma and T. Carell on page 4483 ff..