Design of Porphyrin-dota-Like Scaffolds as All-in-One Multimodal Heterometallic Complexes for Medical Imaging (pages 6629–6643)
Antoine Eggenspiller, Clément Michelin, Nicolas Desbois, Philippe Richard, Jean-Michel Barbe, Franck Denat, Cynthia Licona, Christian Gaiddon, Amira Sayeh, Philippe Choquet and Claude P. Gros
Version of Record online: 26 AUG 2013 | DOI: 10.1002/ejoc.201300678
Multimodal ligands incorporating one porphyrin moiety and one or more dota-like macrocycles in the same molecular architecture have been prepared and fully characterized. Heterometallic complexes incorporating both Gd3+ and Cu2+ ions were also prepared. Preliminary relaxivity, cytotoxicity, and MRI studies showed the complexes are very promising medical imaging agents for bimodal MRI techniques.