Optimized Synthesis and Antimalarial Activity of 1,2-Dioxane-4-carboxamides (pages 1607–1614)
Marco Lombardo, Dhiraj P. Sonawane, Arianna Quintavalla, Claudio Trombini, Dilip D. Dhavale, Donatella Taramelli, Yolanda Corbett, Francesca Rondinelli, Caterina Fattorusso, Marco Persico and Orazio Taglialatela-Scafati
Article first published online: 8 JAN 2014 | DOI: 10.1002/ejoc.201301394
An optimized two-step protocol for the synthesis of 3-methoxy-4-methoxycarbonyl-1,2-dioxanes is reported. This approach is exploited for the synthesis of a new family of 4-carboxamide derivatives with interesting antimalarial activities.