Armochaetoglobins K–R, Anti-HIV Pyrrole-Based Cytochalasans from Chaetomium globosum TW1-1 (pages 3086–3094)
Chunmei Chen, Hucheng Zhu, Jianping Wang, Jing Yang, Xiao-Nian Li, Jing Wang, Keliang Chen, Yanyan Wang, Zengwei Luo, Guangmin Yao, Yongbo Xue and Yonghui Zhang
Article first published online: 30 MAR 2015 | DOI: 10.1002/ejoc.201403678
Eight rare pyrrole-based cytochalasans, armochaetoglobins K–R, were isolated from the solid culture broth of the fungus Chaetomium globosum, first isolated from the arthropod Armadillidium vulgare. Among them, armochaetoglobins L–N, Q, and R showed significant anti-HIV activities, with EC50 values ranging from 0.25 to 0.55 µM, and selective index (SI) values ranging from 20.43 to 75.42.