Rhodium-Catalyzed Vinylic C–H Functionalization of Enol Carbamates with Maleimides (pages 3611–3618)
Satyasheel Sharma, Sang Hoon Han, Hyeim Jo, Sangil Han, Neeraj Kumar Mishra, Miji Choi, Taejoo Jeong, Jihye Park and In Su Kim
Version of Record online: 24 JUN 2016 | DOI: 10.1002/ejoc.201600558
The rhodium(III)-catalyzed direct C–H alkylation of enol carbamates with a range of maleimides is described. With the assistance of the carbamoyl directing group, this reaction provides biologically relevant succinimide compounds by proceeding through a C–Rh addition and subsequent protonation pathway.