Phidéline Gérard, Romain Veillard, Carole Alayrac, Annie-Claude Gaumont and Gwilherm Evano
The cover picture shows the alkynylation of phosphine oxides with copper acetylides. These polymeric, rock-stable and unreactive reagents can be readily activated by coordination with simple ligands and oxidation with molecular oxygen. This activation enables the in situ generation of highly reactive, oxidized copper acetylides that can be trapped by a series of phosphine oxides to give, after a formal reductive elimination step, the corresponding alkynylation product, i.e., alkynylphosphine oxides, which can be readily and easily obtained at room temperature by this mix-and-stir process. Details are discussed in the Communication by C. Alayrac, A.-C. Gaumont, G. Evano et al. on p. 633 ff.