European Journal of Organic Chemistry

Cover image for Vol. 2017 Issue 8

February 24, 2017

Volume 2017, Issue 8

Pages 1151–1183

  1. Front Cover

    1. Top of page
    2. Front Cover
    3. Microreviews
    4. Full Papers
    1. You have free access to this content
      Front Cover: Sphaericin, a Lasso Peptide from the Rare Actinomycete Planomonospora sphaerica (Eur. J. Org. Chem. 8/2017) (page 1151)

      Shinya Kodani, Yuto Inoue, Masahiro Suzuki, Hideo Dohra, Tomohiro Suzuki, Hikaru Hemmi and Mayumi Ohnishi-Kameyama

      Version of Record online: 15 FEB 2017 | DOI: 10.1002/ejoc.201700191

      Thumbnail image of graphical abstract

      The cover picture shows the three-dimensional solution structure of a new lasso peptide sphaericin. Lasso peptides are a class of natural occurring peptides, which possess an isopeptide bond and a common knot structural motif. The uniqueness of a lasso peptide is the three-dimensional structure with a tail part that forms a loop through its own ring. A new lasso peptide named sphaericin was isolated as an antibacterial principle from the rare actinomycete Planomonospora sphaerica. Calculations based on NOE experiments revealed that sphaericin possesses a typical lasso-peptide fold with a ring, a loop, and a tail. Details are discussed in the Full Paper by S. Kodani et al. on page 1177 ff (DOI: 10.1002/ejoc.201601334).

  2. Microreviews

    1. Top of page
    2. Front Cover
    3. Microreviews
    4. Full Papers
    1. Metal-Catalysed Azidation

      You have full text access to this OnlineOpen article
      Metal-Catalysed Azidation of Organic Molecules (pages 1152–1176)

      Monalisa Goswami and Bas de Bruin

      Version of Record online: 22 DEC 2016 | DOI: 10.1002/ejoc.201601390

      Thumbnail image of graphical abstract

      The azide moiety is a desirable functionality in organic molecules, useful in a variety of transformations such as triazole synthesis, aziridination, C–H bond amination, isocyanate synthesis, the Staudinger reaction etc. This review highlights metal-catalysed azidation, which provides shorter routes to a variety of organic molecules of interest, with a focus on substrate scopes and mechanisms.

  3. Full Papers

    1. Top of page
    2. Front Cover
    3. Microreviews
    4. Full Papers
    1. Lasso Peptides

      Sphaericin, a Lasso Peptide from the Rare Actinomycete Planomonospora sphaerica (pages 1177–1183)

      Shinya Kodani, Yuto Inoue, Masahiro Suzuki, Hideo Dohra, Tomohiro Suzuki, Hikaru Hemmi and Mayumi Ohnishi-Kameyama

      Version of Record online: 31 JAN 2017 | DOI: 10.1002/ejoc.201601334

      Thumbnail image of graphical abstract

      The lasso peptide sphaericin is isolated from the rare actinomycete Planomonospora sphaerica. The three-dimensional structure of sphaericin is determined to be the typical lasso structure by NOE experiments.

    2. Diastereoselective Olefination

      Olefination of N-Sulfinylimines under Mild Conditions (pages 1184–1190)

      Shubhendu Dhara and Charles E. Diesendruck

      Version of Record online: 24 FEB 2017 | DOI: 10.1002/ejoc.201601577

      Thumbnail image of graphical abstract

      Imines are very useful directing groups, and, when coupled with a chiral auxiliary such as a sulfoxide group, powerful tools in total synthesis. In this paper, we show that these groups can be converted very efficiently and diastereoselectively into 1,2-disubstituted alkenes (>99:1 E isomer) under very mild conditions.

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