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Enantioselective, Potentiometric Membrane Electrodes for the Determination of L-Pipecolic Acid in Serum
Article first published online: 4 OCT 2004
DOI: 10.1002/elan.200303022
Copyright © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
1521-4109/asset/cover.gif?v=1&s=209b447dcf920ba3fb44f2b08a87a6b586320422 "Electroanalysis")
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How to Cite
Stefan, R.-I., Nejem, R., van Staden, J. and Aboul-Enein, H. (2004), Enantioselective, Potentiometric Membrane Electrodes for the Determination of L-Pipecolic Acid in Serum. Electroanalysis, 16: 1730–1733. doi: 10.1002/elan.200303022
Publication History
- Issue published online: 21 OCT 2004
- Article first published online: 4 OCT 2004
- Manuscript Accepted: 20 FEB 2004
- Manuscript Received: 4 NOV 2003
- Abstract
- References
- Cited By
Keywords:
- Maltodextrins;
- Enantioselective;
- Potentiometric membrane electrodes;
- L-Pipecolic acid
Abstract
L-Pipecolic acid is a marker for peroxisomal disorders. Three enantioselective, potentiometric membrane electrodes were designed for the enantioanalysis of L-pipecolic acid. These electrodes are based on carbon paste impregnated with different maltodextrins (DE: 4.0–7.0 (I), 13.0–17.0 (II) and 16.5–19.5 (III), respectively) as chiral selectors and they can be used reliably for enantiopurity assay of L-pipecolic acid using a potentiometric method in the concentration ranges of 10−8–10−3, 10−8–10−5 and 10−10–10−6 mol/L for the maltodextrins I, II and III, respectively, based electrodes, with very low detection limits (magnitude orders of 10−9 for I and II, respectively and 10−12 mol/L for III). The proposed electrodes can be successfully applied for the enantioanalysis of L-pipecolic acid in serum samples.