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Voltammetric Determination of Trace Antiepileptic Gabapentin with a Silver-Nanoparticle Modified Multiwalled Carbon Nanotube Paste Electrode

Authors

  • Abdollah Yari,

    Corresponding author
    1. Department of Chemistry, Lorestan University, Flakalaflak Street 68137-17133, Khorramabad, Iran tel./fax: +98 661 220185
    • Department of Chemistry, Lorestan University, Flakalaflak Street 68137-17133, Khorramabad, Iran tel./fax: +98 661 220185
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  • Fatemeh Papi,

    1. Department of Chemistry, Lorestan University, Flakalaflak Street 68137-17133, Khorramabad, Iran tel./fax: +98 661 220185
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  • Said Farhadi

    1. Department of Chemistry, Lorestan University, Flakalaflak Street 68137-17133, Khorramabad, Iran tel./fax: +98 661 220185
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Abstract

For the first time, a novel carbon nanotube bed electrode impregnated with silver–nanoparticles (AgNPs) for the determination of trace amounts of gabapentin (GBP) is described. We synthesized the AgNPs via a new procedure. The voltammetric behavior of the electrode was investigated by cyclic voltammetry. There were linear relationships in the ranges from 3.1×10−9 to 2.9×10−2 M and from 1.0×10−8 to 1.0×10−2 GBP with square wave and differential pulse voltammetric peak currents, respectively. The detection limits were 5.6×10−10 and 9.7×10−9 M, respectively. The electrode showed excellent response over a period of 2 months and was successfully applied in human plasma and pharmaceutical capsular products.

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