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Fast Determination of Ciclopirox in Pharmaceutical Products by Amperometry in Flow and Batch Injection Systems

  1. Luís M. C. Ferreira,
  2. Fabiana S. Felix,
  3. Lúcio Angnes*

Article first published online: 10 FEB 2012

DOI: 10.1002/elan.201100713

Issue

Electroanalysis

Electroanalysis

Special Issue: Topical Cluster: Electrochemical Sensors and Biosensors in Italy

Volume 24, Issue 4, pages 961–966, April 2012

Additional Information

How to Cite

Ferreira, L. M. C., Felix, F. S. and Angnes, L. (2012), Fast Determination of Ciclopirox in Pharmaceutical Products by Amperometry in Flow and Batch Injection Systems. Electroanalysis, 24: 961–966. doi: 10.1002/elan.201100713

Author Information

  1. Instituto de Química, Universidade de São Paulo, Instituto de Química, CEP 05508-000, São Paulo, Brazil

*Instituto de Química, Universidade de São Paulo, Instituto de Química, CEP 05508-000, São Paulo, Brazil

Publication History

  1. Issue published online: 30 MAR 2012
  2. Article first published online: 10 FEB 2012
  3. Manuscript Accepted: 18 JAN 2012
  4. Manuscript Received: 20 DEC 2011

Funded by

  • FAPESP
  • CNPq. Grant Number: Project 480311-2009-9
  • CAPES

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Keywords:

  • Ciclopirox olamine;
  • Amperometry;
  • Flow injection analysis;
  • Batch injection analysis;
  • Glassy carbon electrode

Abstract

Amperometry coupled to flow injection analysis (FIA) and to batch injection analysis (BIA) was used for the rapid and precise quantification of ciclopirox olamine in pharmaceutical products. The favourable hydrodynamic conditions provided by both techniques allowed a very high throughput (more than 300 injections per hour) with good linear range (2.0–200 µmol L−1) and low limits of detection (below 1.0 µmol L−1). The results obtained were compared with titration recommended by the American Pharmacopoeia and also using capillary electrophoresis. Good agreement between all results were achieved, demonstrating the good performance of amperometry combined with FIA and BIA.

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