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Monodispersed Gold Nanoparticles Decorated Carbon Nanotubes as an Enhanced Sensing Platform for Nanomolar Detection of Tramadol

Authors

  • Nada F. Atta,

    1. Department of Chemistry, Faculty of Science, Cairo University, Al Gamaa Street, 12613 Giza, Egypt tel.: +20 02 35676561; fax: +20 02 35727556
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  • Rasha A. Ahmed,

    1. Faculty of Science, Taif University, Taif, Saudi Arabia
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  • Hatem M. A. Amin,

    1. Department of Chemistry, Faculty of Science, Cairo University, Al Gamaa Street, 12613 Giza, Egypt tel.: +20 02 35676561; fax: +20 02 35727556
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  • Ahmed Galal

    Corresponding author
    1. Department of Chemistry, Faculty of Science, Cairo University, Al Gamaa Street, 12613 Giza, Egypt tel.: +20 02 35676561; fax: +20 02 35727556
    • Department of Chemistry, Faculty of Science, Cairo University, Al Gamaa Street, 12613 Giza, Egypt tel.: +20 02 35676561; fax: +20 02 35727556
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Abstract

A promising composite-modified glassy carbon electrode is fabricated by electrodeposition of mono-dispersed gold nanoparticles onto carbon nanotubes (AuNPs/CNTs/GCE). The electroanalysis of Tramadol (TRA) was achieved by different electrochemical techniques. The effect of different parameters including pH, concentration and potential scan on the oxidation current signal of TRA was investigated. Large excess of ascorbic acid (AA) and uric acid (UA) with a maximum molar ratio of 1/1000 and 1/100, respectively, did not interfere with the response of TRA. The detection limit with high sensitivity is 68 nM. TRA was successfully determined in pharmaceutical dosage forms, without any pretreatment of the samples.

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