Electrochemical Studies and Selective Detection of Thioridazine Using a Carbon Paste Electrode Modified with ZnS Nanoparticles and Simultaneous Determination of Thioridazine and Olanzapine

Authors

  • Mohammad Hossein Mashhadizadeh,

    Corresponding author
    1. Faculty of Chemistry, Kharazmi (Tarbiat Moallem) University, Tehran, Iran tel: +98 21 88848949, fax: +98 21 88820993
    • Faculty of Chemistry, Kharazmi (Tarbiat Moallem) University, Tehran, Iran tel: +98 21 88848949, fax: +98 21 88820993
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  • Esmaeil Afshar

    1. Faculty of Chemistry, Kharazmi (Tarbiat Moallem) University, Tehran, Iran tel: +98 21 88848949, fax: +98 21 88820993
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Abstract

A novel ZnS nanoparticle-modified carbon paste electrode (ZnSNP-MCPE) was fabricated and used to study the electrooxidation of thioridazine (TR) using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The determination conditions, such as accumulation time, pH of solution, and modifier amount were optimized. The mechanism of the electrooxidation process on the surface of the modified electrode was studied electrochemically. A linear range of 0.1–36.0 µM with detection limit of 65.0 nM was obtained for TR. In a mixture containing TR and olanzapine (OLZ), the DPV peaks of two compounds can be well separate from each other with a potential difference of 425 mV. Finally, this method was successfully applied to determinate the TR content in real samples.

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