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Keywords:

  • Cyclically permuted;
  • Cyclically located;
  • DNA curvature;
  • Theoretical permutation gel electrophoresis

Abstract

Using the theoretical model for DNA curvature, we analyzed a set of fragments with a curved insert located in circular permutation. The theoretical permutation analysis of each of the cyclically located fragments reveals the presence of a shifting molecular bend locus. The delineation of the molecular bend locus associated with the fragments obtained by a second permutation helps in providing an explanation for the differential mobility behavior of the fragments.