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Microfluidic technologies for MALDI-MS in proteomics

  1. Don L. DeVoe Professor1,*,
  2. Cheng S. Lee2

Article first published online: 23 AUG 2006

DOI: 10.1002/elps.200600224

Issue

ELECTROPHORESIS

ELECTROPHORESIS

Special Issue: Microchannel-Based Methods for Proteomics

Volume 27, Issue 18, pages 3559–3568, No. 18 September 2006

Additional Information

How to Cite

DeVoe, D. L. and Lee, C. S. (2006), Microfluidic technologies for MALDI-MS in proteomics. ELECTROPHORESIS, 27: 3559–3568. doi: 10.1002/elps.200600224

Author Information

  1. 1

    Department of Mechanical Engineering, University of Maryland, College Park, MD, USA

  2. 2

    Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA

*Department of Mechanical Engineering, 2129 Glen L. Martin Hall, University of Maryland, College Park, MD 20742, USA Fax: +1-301-314-9477

Publication History

  1. Issue published online: 15 SEP 2006
  2. Article first published online: 23 AUG 2006
  3. Manuscript Received: 11 APR 2006

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Keywords:

  • MALDI;
  • MS;
  • Microfluidics

Abstract

The field of microfluidics continues to offer great promise as an enabling technology for advanced analytical tools. For biomolecular analysis, there is often a critical need to couple on-chip microfluidic sample manipulation with back-end MS. Though interfacing microfluidics to MS has been most often reported through the use of direct ESI-MS, there are compelling reasons for coupling microfluidics to MALDI-MS as an alternative to ESI-MS for both online and offline analysis. The intent of this review is to provide a summary of recent developments in the integration of microfluidic systems with MALDI-MS, with an emphasis on applications in proteomics. Key points are summarized, followed by a review of relevant technologies and a discussion of outlook for the field.

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