Microfluidics and Miniaturization

Chemoselective ligand patterning of electroactive surfaces using microfluidics

  1. Nathan P. Westcott,
  2. Muhammad N. Yousaf*

Article first published online: 2 OCT 2009

DOI: 10.1002/elps.200900275

Issue

ELECTROPHORESIS

ELECTROPHORESIS

Special Issue: ELECTROCHEMISTRY IN MICROFLUIDICS AND CAPILLARY ELECTROPHORESIS

Volume 30, Issue 19, pages 3381–3385, October 2009

Additional Information

How to Cite

Westcott, N. P. and Yousaf, M. N. (2009), Chemoselective ligand patterning of electroactive surfaces using microfluidics. ELECTROPHORESIS, 30: 3381–3385. doi: 10.1002/elps.200900275

Author Information

  1. Department of Chemistry and the Carolina Center for Genome Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

*Department of Chemistry and the Carolina Center for Genome Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, USA Fax: +1-919-962-2388

Publication History

  1. Issue published online: 2 OCT 2009
  2. Article first published online: 2 OCT 2009
  3. Manuscript Accepted: 4 MAY 2009
  4. Manuscript Revised: 3 MAY 2009
  5. Manuscript Received: 28 APR 2009

Funded by

  • NCI
  • Burroughs Wellcome Foundation (Interface Career Award)
  • National Science Foundation (Career Award)

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Keywords:

  • Cell adhesion;
  • Chemoselective;
  • Electrochemistry;
  • Microfluidics;
  • Self-assembled monolayers

Abstract

To generate model substrates for cell adhesion, we have developed two different biocompatible strategies based on self-assembled monolayers (SAMs) of alkanethiolates on gold terminated with latent ketones and aldehydes. Under spatial control, the hydroquinone and alcohol-terminated SAMs can be oxidized to allow for oxyamine ligand patterning on the surface with microfluidic cassettes. These immobilization strategies were characterized by electrochemistry, fluorescence, and utilizing a cell adhesive peptide, cell patterns were generated.

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