Recent advances in capillary electrophoretic migration techniques for pharmaceutical analysis

Authors

  • Sami El Deeb,

    Corresponding author
    1. Drug Analysis and Research Center, Department of Pharmaceutical Chemistry, Al-Azhar University – Gaza, Gaza, Palestine
    2. Institute of Medicinal and Pharmaceutical Chemistry, TU Braunschweig, Braunschweig, Germany
    • Correspondence: Dr. Sami El Deeb, Drug Analysis and Research Center, Department of Pharmaceutical Chemistry, Al-Azhar University – Gaza, Gaza, Palestine

      E-mail: s.deeb@alazhar.edu.ps

      Fax: +97082832913

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  • Hermann Wätzig,

    1. Institute of Medicinal and Pharmaceutical Chemistry, TU Braunschweig, Braunschweig, Germany
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  • Deia Abd El-Hady,

    1. Department of Chemistry, Faculty of Science – North Jeddah, King Abdulaziz University, Jeddah, Saudi Arabia
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  • Hassan M. Albishri,

    1. Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
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  • Cari Sänger-van de Griend,

    1. Kantisto BV, Baarn, The Netherlands
    2. Department of Medicinal Chemistry, Division of Analytical Pharmaceutical Chemistry, Biomedical Centre, Uppsala University, Uppsala, Sweden
    3. Australian Centre for Research on Separation Science (ACROSS), School of Chemistry, University of Tasmania, Hobart, Australia
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  • Gerhard K. E. Scriba

    1. Department of Pharmaceutical and Medicinal Chemistry, School of Pharmacy, Friedrich Schiller University, Jena, Germany
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  • For other Affiliations please see Addendum

  • Colour Online: See the article online to view Figs. 1 and 5 in colour.

Abstract

Since the introduction about 30 years ago, CE techniques have gained a significant impact in pharmaceutical analysis. The present review covers recent advances and applications of CE for the analysis of pharmaceuticals. Both small molecules and biomolecules such as proteins are considered. The applications range from the determination of drug-related substances to the analysis of counterions and the determination of physicochemical parameters. Furthermore, general considerations of CE methods in pharmaceutical analysis are described.

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