Capillary electrophoresis of natural products: 2011–2012

Authors

  • Ria Marni S. Tubaon,

    1. Australian Centre for Research on Separation Science (ACROSS), School of Physical Sciences-Chemistry, University of Tasmania, Hobart, Tasmania, Australia
    Search for more papers by this author
  • Heide Rabanes,

    1. Australian Centre for Research on Separation Science (ACROSS), School of Physical Sciences-Chemistry, University of Tasmania, Hobart, Tasmania, Australia
    2. Chemistry Department, Xavier University, Ateneo de Cagayan, Cagayan de Oro City, Philippines
    3. Department of Chemistry, School of Science and Engineering, Loyola Schools, Ateneo de Manila University, Quezon City, Philippines
    Search for more papers by this author
  • Paul R. Haddad,

    1. Australian Centre for Research on Separation Science (ACROSS), School of Physical Sciences-Chemistry, University of Tasmania, Hobart, Tasmania, Australia
    Search for more papers by this author
  • Joselito P. Quirino

    Corresponding author
    1. Australian Centre for Research on Separation Science (ACROSS), School of Physical Sciences-Chemistry, University of Tasmania, Hobart, Tasmania, Australia
    • Correspondence: Dr. Joselito P. Quirino, Australian Centre for Research on Separation Science (ACROSS), School of Physical Sciences-Chemistry, University of Tasmania, Hobart, Tasmania 7001, Australia

      E-mail: jquirino@utas.edu.au

      Fax: +61-3-6226-2858

    Search for more papers by this author

Abstract

Bioactive natural products are major sources of lead compounds for drug discovery and pharmaceutical development, therefore, innovative and current separation and characterization techniques are important for these compounds. Here, CE methods applied for the analysis of natural products published during 2011–2012 are reviewed. This is an updated version of an earlier review paper in this journal, which highlighted developments during 2006–2010. The major method developments over the review period centered on derivatization, chiral analysis, modes of detection, stacking or on-line sample concentration, and sample preparation (predominantly using extraction methods). The samples analyzed were herbal products, foods, soil, and biological samples. Developments also occurred in the areas of quality control, toxicology assessment, and enzyme-inhibitor screening. A table that summarizes the areas, source of natural product, nature of the bioactive analyte, CE conditions, LODs, and corresponding reference is provided. A short description on the theory of CE and insights on future activities of CE on natural products are also presented.

Ancillary