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Bioanalytical application of surface- and tip-enhanced Raman spectroscopy

Authors

  • Susanne Pahlow,

    1. Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich-Schiller-University Jena, Germany
    2. Institute of Photonic Technology e.V., Jena, Germany
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  • Anne März,

    1. Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich-Schiller-University Jena, Germany
    2. Institute of Photonic Technology e.V., Jena, Germany
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  • Barbara Seise,

    1. Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich-Schiller-University Jena, Germany
    2. Institute of Photonic Technology e.V., Jena, Germany
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  • Katharina Hartmann,

    1. Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich-Schiller-University Jena, Germany
    2. Institute of Photonic Technology e.V., Jena, Germany
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  • Isabel Freitag,

    1. Institute of Photonic Technology e.V., Jena, Germany
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  • Evelyn Kämmer,

    1. Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich-Schiller-University Jena, Germany
    2. Institute of Photonic Technology e.V., Jena, Germany
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  • René Böhme,

    1. Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich-Schiller-University Jena, Germany
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  • Volker Deckert,

    1. Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich-Schiller-University Jena, Germany
    2. Institute of Photonic Technology e.V., Jena, Germany
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  • Karina Weber,

    1. Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich-Schiller-University Jena, Germany
    2. Institute of Photonic Technology e.V., Jena, Germany
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  • Dana Cialla,

    1. Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich-Schiller-University Jena, Germany
    2. Institute of Photonic Technology e.V., Jena, Germany
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  • Jürgen Popp

    Corresponding author
    1. Institute of Photonic Technology e.V., Jena, Germany
    • Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich-Schiller-University Jena, Germany
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Correspondence: Prof. Jürgen Popp (juergen.popp@uni-jena.de, juergen@ipht-jena.de), Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich-Schiller-University Jena, Helmholtzweg 4, 07743 Jena, Germany and Institute of Photonic Technology e.V. Jena, Albert-Einstein-Straße 9, 07745 Jena, Germany.

Abstract

Due to its fingerprint specificity and trace-level sensitivity, surface-enhanced Raman spectroscopy (SERS) is an attractive tool in bioanalytics. This review reflects the research in this highly interesting topic of the last 3–4 years. The detection of the SERS signature of biomolecules up to microorganisms and cells is introduced. Labeling using modified nanoparticles (SERS tags) is also introduced. In order to establish biomedical applications, SERS analysis is performed in complex matrices such as body fluids. Furthermore, the SERS technique is combined with other methods such as microfluidic devices for online monitoring and scanning probe microscopy (i.e. tip-enhanced Raman spectroscopy, TERS) to investigate nanoscaled features. The present review illustrates the broad application fields of SERS and TERS in bioanalytics and shows the great potential of these methods for biomedical diagnostics.

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