Research Article

Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination†‡

  1. Sherine S.L. Chan1,
  2. Janine H. Santos1,
  3. Joel N. Meyer1,
  4. Bhaskar S. Mandavilli1,
  5. Dennis L. Cook Jr.2,
  6. Consuelo L. McCash2,
  7. Grace E. Kissling3,
  8. Abraham Nyska4,
  9. Julie F. Foley4,
  10. Bennett van Houten1,
  11. William C. Copeland1,
  12. Vernon E. Walker2,
  13. Kristine L. Witt5,
  14. Jack B. Bishop5,*

Article first published online: 4 JAN 2006

DOI: 10.1002/em.20191

Issue

Environmental and Molecular Mutagenesis

Environmental and Molecular Mutagenesis

Volume 48, Issue 3-4, pages 190–200, April - May 2007

Additional Information

How to Cite

Chan, S. S.L., Santos, J. H., Meyer, J. N., Mandavilli, B. S., Cook, D. L., McCash, C. L., Kissling, G. E., Nyska, A., Foley, J. F., van Houten, B., Copeland, W. C., Walker, V. E., Witt, K. L. and Bishop, J. B. (2007), Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination. Environ. Mol. Mutagen., 48: 190–200. doi: 10.1002/em.20191

Author Information

  1. 1

    Laboratory of Molecular Genetics, National Institute of Environmental HealthSciences, National Institutes of Health, Research Triangle Park, North Carolina

  2. 2

    Lovelace Respiratory Research Institute, Albuquerque, New Mexico

  3. 3

    Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina

  4. 4

    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina

  5. 5

    Toxicology Operations Branch, National Institute of Environmental HealthSciences, National Institutes of Health, Research Triangle Park, North Carolina

*National Institute of Environmental Health Sciences, PO Box 12233, MD EC-01, Research Triangle Park, NC 27709, USA

  1. †

    This article is a US Government work and, as such, is in the public domain in the United States of America.

  2. ‡

    Invited article on the genotoxicity of perinatal NRTI therapy.

Publication History

  1. Issue published online: 19 MAR 2007
  2. Article first published online: 4 JAN 2006

Funded by

  • NIEHS/NTP. Grant Number: N01-ES-75409
  • NIEHS. Grant Number: P30ES012072
  • National Heart, Lung, and Blood Institute. Grant Number: R01 HL072727

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