Research Article

Transplacental drug transfer and frequency of Tk and Hprt lymphocyte mutants and peripheral blood micronuclei in mice treated transplacentally with zidovudine and lamivudine†‡§

  1. Linda S. Von Tungeln1,
  2. Lee D. Williams1,
  3. Daniel R. Doerge1,
  4. Joseph G. Shaddock2,
  5. Lynda J. McGarrity2,
  6. Suzanne M. Morris2,
  7. Roberta A. Mittelstaedt2,
  8. Robert H. Heflich2,
  9. Frederick A. Beland1,*

Article first published online: 18 JUL 2006

DOI: 10.1002/em.20237

Issue

Environmental and Molecular Mutagenesis

Environmental and Molecular Mutagenesis

Volume 48, Issue 3-4, pages 258–269, April - May 2007

Additional Information

How to Cite

Von Tungeln, L. S., Williams, L. D., Doerge, D. R., Shaddock, J. G., McGarrity, L. J., Morris, S. M., Mittelstaedt, R. A., Heflich, R. H. and Beland, F. A. (2007), Transplacental drug transfer and frequency of Tk and Hprt lymphocyte mutants and peripheral blood micronuclei in mice treated transplacentally with zidovudine and lamivudine. Environ. Mol. Mutagen., 48: 258–269. doi: 10.1002/em.20237

Author Information

  1. 1

    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas

  2. 2

    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas

*National Center for Toxicological Research, Jefferson, AR 72079, USA

  1. †

    Invited article on the genotoxicity of perinatal NRTI therapy.

  2. ‡

    The views expressed in this article do not necessarily reflect those of the Food and Drug Administration.

  3. §

    This article is a US Government work and, as such, is in the public domain in the United States of America.

Publication History

  1. Issue published online: 19 MAR 2007
  2. Article first published online: 18 JUL 2006

Funded by

  • National Center for Toxicological Research
  • Food and Drug Administration and National Institute for Environmental Health Sciences
  • National Toxicology Program. Grant Number: Interagency Agreement No.: 224-93-0001

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