Research Article

Frequency of Hprt mutant lymphocytes and micronucleated erythrocytes in p53-haplodeficient mice treated perinatally with AZT and AZT in combination with 3TC†‡

  1. Vasily N. Dobrovolsky1,*,
  2. Joseph G. Shaddock1,
  3. Roberta A. Mittelstaedt1,
  4. Michelle E. Bishop1,
  5. Sherry M. Lewis2,
  6. Fei W. Lee2,
  7. Anane Aidoo1,
  8. Julian E.A. Leakey2,
  9. June K. Dunnick3,
  10. Robert H. Heflich1

Article first published online: 14 MAR 2007

DOI: 10.1002/em.20280

Issue

Environmental and Molecular Mutagenesis

Environmental and Molecular Mutagenesis

Volume 48, Issue 3-4, pages 270–282, April - May 2007

Additional Information

How to Cite

Dobrovolsky, V. N., Shaddock, J. G., Mittelstaedt, R. A., Bishop, M. E., Lewis, S. M., Lee, F. W., Aidoo, A., Leakey, J. E.A., Dunnick, J. K. and Heflich, R. H. (2007), Frequency of Hprt mutant lymphocytes and micronucleated erythrocytes in p53-haplodeficient mice treated perinatally with AZT and AZT in combination with 3TC. Environ. Mol. Mutagen., 48: 270–282. doi: 10.1002/em.20280

Author Information

  1. 1

    US Food and Drug Administration, Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas

  2. 2

    Office of Scientific Coordination, National Center for Toxicological Research, Jefferson, Arkansas

  3. 3

    National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, North Carolina

*3900 NCTR Rd., HFT-120, Jefferson, AR 72079, USA

  1. †

    This article is a US Government work and, as such, is in the public domain in the United States of America.

  2. ‡

    Invited article on the genotoxicity of perinatal NRTI therapy.

Publication History

  1. Issue published online: 19 MAR 2007
  2. Article first published online: 14 MAR 2007

Funded by

  • National Center for Toxicological Research (Food and Drug Administration);
  • National Institute for Environmental Health Sciences (National Toxicology Program)

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