Research Article

Plasma and cellular markers of 3′-azido-3′-dideoxythymidine (AZT) metabolism as indicators of DNA damage in cord blood mononuclear cells from infants receiving prepartum NRTIs†‡

  1. Quanxin Meng1,2,3,
  2. Ofelia A. Olivero4,
  3. Michael J. Fasco1,2,
  4. Ronald Bellisario1,
  5. Laurence Kaminsky1,2,
  6. Ken A. Pass1,2,
  7. Nancy A. Wade5,
  8. Elaine J. Abrams6,
  9. Carol J. Nesel7,
  10. Roberta B. Ness8,
  11. William L. Bigbee8,9,
  12. J. Patrick O'Neill10,
  13. Dale M. Walker1,3,11,
  14. Miriam C. Poirier4,
  15. Vernon E. Walker1,2,3,11,*

Article first published online: 14 MAR 2007

DOI: 10.1002/em.20298

Issue

Environmental and Molecular Mutagenesis

Environmental and Molecular Mutagenesis

Volume 48, Issue 3-4, pages 307–321, April - May 2007

Additional Information

How to Cite

Meng, Q., Olivero, O. A., Fasco, M. J., Bellisario, R., Kaminsky, L., Pass, K. A., Wade, N. A., Abrams, E. J., Nesel, C. J., Ness, R. B., Bigbee, W. L., O'Neill, J. P., Walker, D. M., Poirier, M. C. and Walker, V. E. (2007), Plasma and cellular markers of 3′-azido-3′-dideoxythymidine (AZT) metabolism as indicators of DNA damage in cord blood mononuclear cells from infants receiving prepartum NRTIs. Environ. Mol. Mutagen., 48: 307–321. doi: 10.1002/em.20298

Author Information

  1. 1

    Wadsworth Center, New York State Department of Health, Albany, New York

  2. 2

    School of Public Health, University at Albany, State University of New York, Albany, New York

  3. 3

    Lovelace Respiratory Research Institute, Albuquerque, New Mexico

  4. 4

    Carcinogen-DNA Interactions Section, National Cancer Institute, NIH, Bethesda, Maryland

  5. 5

    Department of Pediatrics, Children's Hospital at Albany Medical Center, Albany, New York

  6. 6

    Department of Pediatrics, Columbia University College of Physicians and Surgeons and Harlem Hospital Center, New York, New York

  7. 7

    Westat Inc., Rockville, Maryland

  8. 8

    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania

  9. 9

    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania

  10. 10

    Genetics Laboratory, University of Vermont, Burlington, Vermont

  11. 11

    College of Pharmacology, University of New Mexico, Albuquerque, New Mexico

*Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108

  1. †

    Invited article on the genotoxicity of perinatal NRTI therapy.

  2. ‡

    Contributing investigators at clinical sites for the protocol entitled “A study of the potential mutagenicity of ZDV/nucleoside analogues in perinatal HIV prophylaxis” were Alan Bateman (Harlem Hospital Center, New York, NY), Eleanor Jimenez and Jorge Gandia (Centro Medico, San Juan, Puerto Rico), Renee Samelson (Albany Medical Center, Albany, NY), Sohail Rana (Howard University Hospital, Washington, DC), Andrea Kovacs and Alice Stek (University of Southern California Medical Center, Los Angeles, CA), and Mobeen H. Rathore and Isaac Delke (University of Florida Health Science Center, Jacksonville, FL).

Publication History

  1. Issue published online: 19 MAR 2007
  2. Article first published online: 14 MAR 2007

Funded by

  • National Institute of Child Health and Human Development
  • National Cancer Institute
  • Office of AIDS Research. Grant Numbers: R01 HD33648, R01CA95741

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