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Key studies used to support cancer risk assessment questioned†
Article first published online: 22 JUL 2011
Copyright © 2011 Wiley-Liss, Inc.
Environmental and Molecular Mutagenesis
Volume 52, Issue 8, pages 595–606, October 2011
How to Cite
Calabrese, E. J. (2011), Key studies used to support cancer risk assessment questioned. Environ. Mol. Mutagen., 52: 595–606. doi: 10.1002/em.20662
- Issue published online: 10 OCT 2011
- Article first published online: 22 JUL 2011
- Manuscript Accepted: 1 JUN 2011
- Manuscript Received: 27 MAY 2011
- Air Force Office of Scientific Research, Air Force Material Command, USAF. Grant Number: FA9550-07-1-0248
- ionizing radiation;
- risk assessment;
This paper reassessed studies conducted under the leadership of Drosophila geneticist Curt Stern which played a pivotal role in the acceptance of the linear dose-response model by the U.S. National Academy of Sciences Biological Effects of Atomic Radiation (BEAR) I Committee and the subsequent generalization of their recommendations on the linearity dose-response paradigm for ionizing radiation and chemically induced cancer. The analysis finds serious concerns and flaws in important aspects of these experiments, their assessment, and interpretation. Of particular concern was the failure of Stern's group to provide the necessary and promised experimental documentation to support the findings of three critical summarized experiments published as a brief technical note in Science. While this analysis questions the validity of the reported findings and their interpretations, it raises an even more serious concern about the process by which leaders in the radiation genetics community accepted such findings without requiring the necessary documentation and then used this information to support the acceptance of the linear dose-response in public policy matters as affected by risk assessment practices that have continued to the present. Environ. Mol. Mutagen. 2011. © 2011 Wiley-Liss, Inc.