Cell type-dependent gene transcription profile in a three-dimensional human skin tissue model exposed to low doses of ionizing radiation: Implications for medical exposures
Article first published online: 20 FEB 2012
Copyright © 2012 Wiley Periodicals, Inc.
Environmental and Molecular Mutagenesis
Volume 53, Issue 4, pages 247–259, May 2012
How to Cite
von Neubeck, C., Shankaran, H., Karin, N. J., Kauer, P. M., Chrisler, W. B., Wang, X., Robinson, R. J., Waters, K. M., Tilton, S. C. and Sowa, M. B. (2012), Cell type-dependent gene transcription profile in a three-dimensional human skin tissue model exposed to low doses of ionizing radiation: Implications for medical exposures. Environ. Mol. Mutagen., 53: 247–259. doi: 10.1002/em.21682
- Issue published online: 9 APR 2012
- Article first published online: 20 FEB 2012
- Manuscript Accepted: 11 JAN 2012
- Manuscript Revised: 6 JAN 2012
- Manuscript Received: 4 NOV 2011
- US Department of Energy. Grant Number: DE-AC06-76RLO
- National Aeronautics and Space Administration. Grant Number: NNX10AB06G
- Biological and Environmental Research Program (BER)
Additional Supporting Information may be found in the online version of this article.
|EM_21682_sm_SuppTab1.doc||72K||Supporting Information Table 1. Enrichment of annotation terms in up- and down-regulated probes in the dermis. Functional enrichment analysis was performed using DAVID as detailed in Methods. aTotal number of statistically significant probes in the up/down regulated lists at the indicated time point. bActual annotation term from DAVID or a representative term for an annotation cluster with geometric mean (GM) p value ≤ 0.01. The latter are highlighted using an asterisk (*) next to the term. cThe minimum p value is presented for annotation clusters with GM p value ≤ 0.01. The actual p value is presented for all other individual terms (terms with p ≤ 0.01 that belong to clusters with GM p value > 0.01, or orphan terms that are not part of any of the annotation clusters).|
|EM_21682_sm_SuppTab2.doc||50K||Supporting Information Table 2. Enrichment of annotation terms in up- and down-regulated probes in the epidermis. Functional enrichment analysis was performed using DAVID as detailed in Methods. See Sup. Table 1 for description of terminology.|
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