Research Article

Cell type-dependent gene transcription profile in a three-dimensional human skin tissue model exposed to low doses of ionizing radiation: Implications for medical exposures

  1. Claere von Neubeck1,
  2. Harish Shankaran2,
  3. Norman J. Karin1,
  4. Paula M. Kauer1,
  5. William B. Chrisler1,
  6. Xihai Wang1,
  7. R. Joe Robinson1,
  8. Katrina M. Waters2,
  9. Susan C. Tilton2,
  10. Marianne B. Sowa1,*

Article first published online: 20 FEB 2012

DOI: 10.1002/em.21682

Issue

Environmental and Molecular Mutagenesis

Environmental and Molecular Mutagenesis

Volume 53, Issue 4, pages 247–259, May 2012

Additional Information

How to Cite

von Neubeck, C., Shankaran, H., Karin, N. J., Kauer, P. M., Chrisler, W. B., Wang, X., Robinson, R. J., Waters, K. M., Tilton, S. C. and Sowa, M. B. (2012), Cell type-dependent gene transcription profile in a three-dimensional human skin tissue model exposed to low doses of ionizing radiation: Implications for medical exposures. Environ. Mol. Mutagen., 53: 247–259. doi: 10.1002/em.21682

Author Information

  1. 1

    Department of Systems Toxicology, Pacific Northwest National Laboratory, Richland, Washington

  2. 2

    Department of Computational Biology and Bioinformatics, Pacific Northwest National Laboratory, Richland, Washington

*Pacific Northwest National Laboratory, P.O. Box 999, MS J4-02, Richland, WA 99352, USA

Publication History

  1. Issue published online: 9 APR 2012
  2. Article first published online: 20 FEB 2012
  3. Manuscript Accepted: 11 JAN 2012
  4. Manuscript Revised: 6 JAN 2012
  5. Manuscript Received: 4 NOV 2011

Funded by

  • US Department of Energy. Grant Number: DE-AC06-76RLO
  • National Aeronautics and Space Administration. Grant Number: NNX10AB06G
  • Biological and Environmental Research Program (BER)

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FilenameFormatSizeDescription
EM_21682_sm_SuppFile1.xlsx9211KSupporting Information
EM_21682_sm_SuppFile2.xlsx2577KSupporting Information
EM_21682_sm_SuppTab1.doc72KSupporting Information Table 1. Enrichment of annotation terms in up- and down-regulated probes in the dermis. Functional enrichment analysis was performed using DAVID as detailed in Methods. aTotal number of statistically significant probes in the up/down regulated lists at the indicated time point. bActual annotation term from DAVID or a representative term for an annotation cluster with geometric mean (GM) p value ≤ 0.01. The latter are highlighted using an asterisk (*) next to the term. cThe minimum p value is presented for annotation clusters with GM p value ≤ 0.01. The actual p value is presented for all other individual terms (terms with p ≤ 0.01 that belong to clusters with GM p value > 0.01, or orphan terms that are not part of any of the annotation clusters).
EM_21682_sm_SuppTab2.doc50KSupporting Information Table 2. Enrichment of annotation terms in up- and down-regulated probes in the epidermis. Functional enrichment analysis was performed using DAVID as detailed in Methods. See Sup. Table 1 for description of terminology.

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